For the quaternary ammonium salt with cation 5, K S equals 6.6♱0 6 M –1. The electrostatic interaction of the side chain of NDI with DNA makes a significant contribution to the stability of the intercalation complex. The binding constants of NDI derivative 12 with G4 of various types (human telomeric DNA, quadruplexes in the promoter region of the KRAS, c- MYC, and thrombinbinding aptamer genes) are up to 270 times greater than the binding constant of NDI 12 with dsDNA (binding constants were determined by spectrophotometric titration). Plus the program can save all images that were found on the same page, where the original full-size image is located - the related images.Compound 12 exhibits a high affinity for binding to DNA G4 ( K S 10 6–10 7 М –1) in comparison with dsDNA. Of course, you can make Extreme Picture Finder find, download and save both thumbnails and full-size images automatically, or only full-size images. Then you can choose which full-size images to download manually. You can let the program find and download only thumbnails and you'll see hundreds of images flying to you in a matter of seconds - this is the fastest search mode. It has different search modes allowing you vary the level of your interaction with the download process. Just enter the keyword and the program will find and download thousands of pictures for you. Another great feature of the program is, as the name suggests, a built-in picture finder. Don't know where to start downloading? Extreme Picture Finder offers a built-in online projects database with thousands of website addresses sorted by category: Desktop Wallpapers, Cars, Girls, Nature and many, many others. Using advanced settings you can make Extreme Picture Finder skip certain parts of websites, like entire folders or single pages to make the download process even faster. The program can be configured to download images from password-protected websites, forum threads, and even social networks. And you can instantly view the downloaded files in the built-in image viewer. But not only images! You can download music, video or any other files - just enter the website address, choose what files to download and where to save them and let Extreme Picture Finder do the rest for you. It allows you to download all images from any website automatically and very fast. Extreme Picture Finder is powerful batch image downloader software.
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